TLR Antagonism by Sparstolonin B Alters Microbial Signature and Modulates Gastrointestinal and Neuronal Inflammation in Gulf War Illness Preclinical Model

The Gulf War and illness by association.

The symptoms of Gulf War Syndrome (GWS) closely correspond to the physiological and behavioural sequelae of an interleukin-1 (IL-1) mediated sickness response. We propose that this response can account for the variability in its symptomatology. Furthermore, the persistence of GWS can be accounted for by an associative process, whereby the smells/tastes of war become linked with the physiologica...

Blood Biomarkers of Chronic Inflammation in Gulf War Illness

BACKGROUND More than twenty years following the end of the 1990-1991 Gulf War it is estimated that approximately 300,000 veterans of this conflict suffer from an unexplained chronic, multi-system disorder known as Gulf War Illness (GWI). The etiology of GWI may be exposure to chemical toxins, but it remains only partially defined, and its case definition is based only on symptoms. Objective cri...

A Neuroimmune Model of Gulf War Illness

Several studies have implicated immune system disruption in the pathophysiology of GWI. In addition, alterations in brain structure and functioning have been associated with specific exposures in theater, including pyridostigmine bromide and nerve gas agents. Recent studies conducted up to 25 years after the 1991 conflict have examined factors associated with the continuation or worsening of GW...

Update on Gulf War illness.

Background: Cryptic species are two or more distinct but morphologically similar species that were classified as a single species. During the past two decades we observed an exponential growth of publications on cryptic species. Recently published reviews have demonstrated cryptic species have profound consequences on many biological disciplines. It has been proposed that their distribution is ...

Gulf War Illness and the Health of Gulf War Veterans Scientific Findings and Recommendations Research Advisory Committee on Gulf War Veterans’ Illnesses Gulf War Illness and the Health of Gulf War Veterans Scientific Findings and Recommendations